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Diagnosing And Predicting Development Of Rheumatoid Arthritis

Viernes, Marzo 26, 2021

The treatment of rheumatoid arthritis is fraught with unknowns. It is not always certain how active the patient’s arthritis may be, even while they are engaged in an effective treatment regimen. What factors may predict a flare of the disease and how to confirm that the patient remains in remission are unknown.






Determination of Brain Death/Death by Neurological Criteria: The World Brain Death Project

Viernes, Marzo 26, 2021

The first consensus recommendations on the topic aim to address variation in diagnosis at the international, national, and local levels.

Sponsoring Organization: World Brain Death Project, assisted by international professional societies including the World Federation of Intensive and Critical Care, World Federation of Pediatric Intensive and Critical Care Societies, World Federation of Neurology, World Federation of Neurosurgery, and the World Federation of Critical Care Nurses.






Benefits Of Metabolic Surgery

Viernes, Marzo 26, 2021

A plethora of studies comparing the metabolic benefits of bariatric surgery with usual medical management of obese patients has increased the focus on surgical management — either Roux-en-Y gastric bypass or, increasingly often, sleeve gastrectomy. 






Can Retinal Thickness Predict Cognitive Decline in Parkinson Disease?

Viernes, Marzo 26, 2021

In a small study, two measures of retinal thickness showed greater thinning rates and correlations with cognitive decline in patients with PD than in controls.
Increasing interest has focused on the development of biomarkers capable of tracking Parkinson disease (PD) progression over time.






Association Between Migraine with Aura and Cryptogenic Ischemic Stroke in the Young

Viernes, Marzo 26, 2021

A strong relationship was seen in both women and men, irrespective of the presence of PFO.
Previous studies have evaluated some of the complex relationships among cryptogenic stroke, migraine, and patent foramen ovale (PFO) and suggested the following: Migraine is associated with ischemic stroke, migraine with aura is associated with the presence of PFO, and the association between mi-graine and cryptogenic ischemic stroke is stronger among patients with PFO than without. 






Guidance in Evaluation of Microscopic Hematuria

Viernes, Marzo 26, 2021

A new guideline recommends ultrasound instead of computed tomography for some patients with this finding.
How should we evaluate asymptomatic microscopic hematuria? A 2012 guideline from the American Urological Association (AUA) recommended that all patients older than 35 with microscopic hema-turia — defined by the AUA as ≥ 3 red cells per high-power field — should undergo both computed  tomography urography (CTU) and cystoscopy. 






Amyloid Burden: A Reason for Poor Antidepressant Response in Late-Life Depression?

Lunes, Marzo 1, 2021

In cognitively intact individuals with late-life depression, cortical amyloid burden predicted poor antidepressant response. 
Accumulation of cortical amyloid-β (Aβ) has been associated with greater depressive symptoms in cognitively intact older adults. 






Safety and Efficacy of Extreme Blood Pressure Lowering in Intracerebral Hemorrhage

Lunes, Marzo 1, 2021

Safety and Efficacy of Extreme Blood Pressure Lowering  in Intracerebral Hemorrhage
Higher rates of neurologic deterioration and adverse events were associated with intensive treatment in patients with excessively high initial systolic blood pressure. Many patients with intracerebral hemorrhage (ICH) present with elevated systolic blood pressure (SBP). At times, SBP can be markedly elevated (>220 mm Hg). 





Psychiatric Disorders Across the Life Span: A Unitary Psychopathology Factor Best Fits the Data

Lunes, Marzo 1, 2021

A 45-year longitudinal study shows that mental illness is astonishingly common and that it’s better to be a “lumper” than a “splitter” when thinking diagnostically.
Cross-sectional epidemiological surveys have documented high rates of lifetime psychiatric disorders (about 40%–50%) and substantial comorbidity,






Lunes, Marzo 1, 2021

Letter from the Editor
About one in four older Americans fall each year, resulting in about 30,000 deaths and 800,000 hospitalizations annually.





POEMS Syndrome: Clinical Features and Outcomes in a U.K. Cohort

Lunes, Marzo 1, 2021

A retrospective analysis of cases shows that smooth meningeal thickening provides an additional diagnostic clue differentiating POEMS syndrome from chronic immune demyelinating polyneuropathy.
POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin lesions) is a rare but treatable paraneoplastic disorder of plasma cells associated with sensorimotor polyneuropathy,